Two years after the events in Bangkok, Leslie Chow (Ken Jeong) escapes from a maximum security prison, using a riot as cover. Meanwhile, in the United States, Alan Garner (Zach Galifianakis) causes a multi-car freeway pileup after he purchases a giraffe and accidentally decapitates it on a low overpass. Alan’s father Sid (Jeffrey Tambor), angry with Alan for his immature antics and never owning up to his mistakes, dies of a heart attack in the middle of a lecture. After the funeral, Alan’s brother-in-law Doug Billings (Justin Bartha) informs friends Phil Wenneck (Bradley Cooper) and Stu Price (Ed Helms) that Alan has been off his ADHD medication and is out of control.